An elevated body temperature is the most widely recognized clinical sign indicating the presence of an infection. Fever is the natural response to invasion of the body defenses by a… Click to show full abstract
An elevated body temperature is the most widely recognized clinical sign indicating the presence of an infection. Fever is the natural response to invasion of the body defenses by a microbe and arises as a result of a complex interplay between endogenous and exogenous pyrogens (1). Infection-associated severe sepsis and septic shock are characterized by impairment of homeostatic mechanisms in a range of body systems. Although patients with severe sepsis and septic shock may present with normal or abnormal body temperatures, hypothermia associated with septic shock portends the worst outcome.
               
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