LAUSR

REFERENCES 1. Kaukonen KM, Bailey M, Suzuki S, et al: Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 2014; 311:1308–1316 2. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589–1596 3. Kumar A, Ellis P, Arabi Y, et al; Cooperative Antimicrobial Therapy of Septic Shock Database Research Group: Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136:1237–1248 4. Rhodes A, Evans LE, Alhazzani W, et al: Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016. Crit Care Med 2017; 45:486–552 5. Kelesidis T, Braykov N, Uslan DZ, et al: Indications and types of antibiotic agents used in 6 acute care hospitals, 2009-2010: A pragmatic retrospective observational study. Infect Control Hosp Epidemiol 2016; 37:70–79 6. Drusano GL: Antimicrobial pharmacodynamics: Critical interactions of ‘bug and drug’. Nat Rev Microbiol 2004; 2:289–300 7. Lodise TP Jr, Lomaestro B, Drusano GL: Piperacillin-tazobactam for Pseudomonas aeruginosa infection: Clinical implications of an extended-infusion dosing strategy. Clin Infect Dis 2007; 44:357–363 8. Bauer KA, West JE, O’Brien JM, et al: Extended-infusion cefepime reduces mortality in patients with Pseudomonas aeruginosa infections. Antimicrob Agents Chemother 2013; 57:2907–2912 9. Chastre J, Wunderink R, Prokocimer P, et al: Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: A multicenter, randomized study. Crit Care Med 2008; 36:1089–1096 10. Rhodes NJ, Liu J, O’Donnell JN, et al: Prolonged Infusion PiperacillinTazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis. Crit Care Med 2018; 46:236–243 11. George JM, Colton BJ, Rodvold KA: National survey on continuous and extended infusions of antibiotics. Am J Health Syst Pharm 2012; 69:1895–1904