LAUSR

was 11.3 mmol/L and his HbA1c was 8.2% at 14 years To the Editor: Neonatal diabetes mellitus (NDM) is defined as diabetes diagnosed within 6 months after birth old. We conducted a 2h-oral glucose tolerance test and occurs in approximately one in every 90,000 to 160,000 live births, with an 80% yield due to a known genetic diagnosis. NDM can be classified as transient (TNDM), permanent (PNDM), or syndromic, in which TNDM accounts for approximately 45% of all cases of NDM. Overexpression of genes on chromosome 6q24 is the most common cause of TNDM (OMIM_601410), which accounts for approximately 70% of all cases and occurs by one of three mechanisms: (1) paternal uniparental disomy (41%), (2) duplication of paternal alleles (33%), or (3) hypomethylation of the maternal allele (26%). TNDM can be characterized as small for gestational age and yield a “Diabetes-RemissionRelapse” natural history, where insulin is deemed to be the original treatment. However, there is no standard treatment for relapsed patients. Hence, we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride.