LAUSR

Celiac disease (CD), once considered a gastrointestinal 1.77% (7/395) among patients with diarrhea-predominant condition, is now known as a systemic autoimmune disease irritable bowel syndrome (IBS), and four out of these seven initiated by exposure to dietary gluten mainly in human leukocyte antigen DQ2 (HLA-DQ2) or HLA-DQ8 carriers. The classic presentations of CD include intestinal manifestations such as chronic diarrhea, bloating, abdominal pain, constipation, weight loss, or poor growth in children. Iron-deficiency, osteoporosis, and neuropathy attributable to vitamin B12 deficiency is also frequently seen in celiac patients. Immune responses spreading to tissues apart from the intestine cause dermatologic conditions such as dermatitis herpetiformis, and even increased risk of miscarriage in women.