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The patient’s clinical symptoms improved after treatment To the Editor: Mitochondrial diseases are a common group of human genetic diseases that can occur at any with vitamins, lipoic acid, and coenzymes. However, he decade of life. Mitochondrial DNA (mtDNA) mutations are responsible for most adult-onset mitochondrial diseases. There are over 260 known pathogenic mutations in mtDNA. In the last two decades, a large number of pathogenic mutations of mtDNA have been reported, which associate with a wide spectrum of clinical features.