LAUSR

The World Health Organization has recently declared the Atlas (https://www.proteinatlas.org/ENSG000001302342019-novel coronavirus (2019-nCoV) a global public ACE2/tissue). health emergency. Huang et al reported acute kidney injury (AKI) in 7% of the 41 patients infected with 2019nCoV, this value was even higher (up to 31%) among intensive-care patients. Furthermore, Li et al reported that plasma creatinine levels increased in 11 of 59 patients with 2019-nCoV infection, suggesting that kidney function was probably impaired when the disease progressed. Guan et al reported that plasma creatinine level increased in 4.3% of severely diseased patients. 2019-nCoV is a highly contagious pathogen that predominantly causes pneumonic symptoms. Although respiratory failure has been associated with the highest mortality, the lung was not the only organ involved. Hoffmann et al reported that 2019-nCoV and severe acute respiratory syndromeassociated coronavirus (SARS-CoV) share a common receptor angiotensin-converting enzyme 2 (ACE2) that is required to enter target cells, and cellular protease transmembrane protease serine 2 (TMPRSS2) can cleave and activate the spike protein of 2019-nCoV for membrane fusion. We investigated whether ACE2 and TMPRSS2 were expressed in kidney cells using precisiontechnology single-cell RNA sequencing.