LAUSR

Insulin treatment has many cutaneous alterations and skinrelated adverse effect, lipohypertrophy (LH) is the commonest among them. LH has the definition with a tumor-like lump, visible and touchable, adipose tissue at the site of insulin injection. It might result from the lipogenic effect of repeated insulin exposure. Injecting insulin into the tissue with LH weakens insulin physiological function, and leads to a resulting excess glucose exposure, glycemic modifiability, and an increased risk of hypoglycemia. Unfortunately, there is limited information about the pathophysiology of LH in insulin users. As a result, reports of prevalence, clinical consequence, and pathogenesis are needed.