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Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation

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To the Editor: Bronchial asthma is a respiratory disease with pathological features that mainly comprise changes in airway inflammation, airway remodeling, and airway hyperresponsiveness. During an asthma attack, a large… Click to show full abstract

To the Editor: Bronchial asthma is a respiratory disease with pathological features that mainly comprise changes in airway inflammation, airway remodeling, and airway hyperresponsiveness. During an asthma attack, a large number of inflammatory genes are activated, and the expression of inflammatorymediators increases, eventually leading to airway hyperresponsiveness and remodeling. Nuclear factor-kB (NF-kB) is composedof transcriptionally active dimers of the Rel family, which is closely related to the expression of inflammatory genes during an asthma attack.

Keywords: inflammation asthmatic; related inflammation; regulates related; asthmatic mice; deacetylase regulates; histone deacetylase

Journal Title: Chinese Medical Journal
Year Published: 2022

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