To the Editor: Primary generalized glucocorticoid hypersensitivity is a rare condition characterized by generalized, partial target-tissue hypersensitivity to glucocorticoids. Therefore, low concentration of glucocorticoids is suf fi - cient to… Click to show full abstract
To the Editor: Primary generalized glucocorticoid hypersensitivity is a rare condition characterized by generalized, partial target-tissue hypersensitivity to glucocorticoids. Therefore, low concentration of glucocorticoids is suf fi - cient to effectively maintain the patient ’ s cell physiological effects and to suppress the hypothalamic-pituitary-adrenal axis. Our study aims to provide some insight into when glucocorticoid hypersensitivity should be considered and how to diagnose it. We also propose a diagnostic fl ow chart for glucocorticoid hypersensitivity for the fi rst time based on our experience and previous literature review. The study was reviewed and approved by the Institutional
               
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