LAUSR

Multiple myeloma (MM) is a hematologic malignancy in which plasma cells proliferate in the bone marrow, leading to osteolytic bone destruction. Bone involvement is present in up to 90% of patients with MM and is associated with pain and skeletal-related complications, such as pathologic vertebral compression fractures (VCFs). [1] MM-associated VCFs cause spinal instability, back pain, spinal kyphosis, neurologic dysfunction, and subsequent respiratory complications, which markedly decrease the quality of life of affected patients. Patients with MM-associated VCFs without neurological involvement can undergo vertebral augmentation, including percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP). [2] In recent years, preliminary studies have demonstrated the effectiveness of PVP or PKP in controlling the pain and improving the quality of life of patients with MM-associated VCFs. [2] However, these studies have shortcomings of small sample sizes (24 – 108 patients) and short follow-up time (3 – 36 months). Most of these studies focused on clinical function, but few studies focused on complications and the incidence of long-term subsequent fractures after vertebral augmentation. This retrospective study aimed to evaluate the longterm clinical outcomes and complications of PVP combined with chemotherapy for MM-associated VCFs without neurological involvement. This