Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as a first-line drug for axSpA patients. Failed to NSAIDs therapy, tumor necrosis factor (TNF)-a inhibitor (TNFi) was suggested in the treatment strategy of… Click to show full abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as a first-line drug for axSpA patients. Failed to NSAIDs therapy, tumor necrosis factor (TNF)-a inhibitor (TNFi) was suggested in the treatment strategy of axSpA. But 30% of axSpA patients still do not respond or respond inadequately to the TNFi therapy. Moreover, TNF-a antagonists are believed to have a weak effect on preventing osteophyte formation and spinal structure damage in axSpA.
               
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