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Metagenomic next-generation sequencing for the diagnosis of Pneumocystis jirovecii pneumonia in solid organ transplant recipients

To the Editor: Pneumocystis jirovecii (P. jirovecii) pneumonia (PJP) is an opportunistic infection that usually occurs in immunosuppressed patients. Solid organ transplant (SOT) recipients have a high incidence of PJP… Click to show full abstract

To the Editor: Pneumocystis jirovecii (P. jirovecii) pneumonia (PJP) is an opportunistic infection that usually occurs in immunosuppressed patients. Solid organ transplant (SOT) recipients have a high incidence of PJP due to the use of immunosuppressive therapy. In recent years, metagenomic next-generation sequencing (mNGS) has been increasingly used in the diagnosis of infectious diseases. Herein, we report ten cases of PJP diagnosed by mNGS and compare the diagnostic value of mNGS with that of conventional laboratory methods.

Keywords: pneumocystis jirovecii; metagenomic next; jirovecii; organ transplant; solid organ; jirovecii pneumonia

Journal Title: Chinese Medical Journal
Year Published: 2022

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