LAUSR

To The Editor: Acne vulgaris is a chronic in fl ammatory skin disease involving the sebaceous glands. It has an incidence of approximately 9.4%, often occurring in adolescents. [1] The disease itself and the scars left after treatment can cause psychological stress in adolescents and seriously affect patients ’ quality of life. [2] At present, skin care products, either alone or in combination with medical drugs, have become important means for treating acne. This single-center, single-blind (clinician-blind), masculine-paralleled, randomized study (Registration number: ChiCTR2100051398) evaluated the ef fi cacy and safety of a cream containing octyl salicylic acid, salicylic acid, linoleic acid, nicotinamide, and piroctone olamine (Duo+, La Roche-Posay, Paris, France) alone and in combination with benzoyl peroxide (BPO, Galderma, Paris, France) for the treatment of mild-to-moderate acne. The research was approved by the Ethics Committee of Shanghai Skin Disease Hospital, China (No. 2020-13 ke). All participants provided written informed consent. 67 patients were