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To the Editor: Extra-mammary Paget’s disease (EMPD) is a rare cutaneous intra-epidermal adenocarcinoma with a controversial origin, and frequently occurs in the penoscrotal region in males. Primary EMPD, which originates… Click to show full abstract
To the Editor: Extra-mammary Paget’s disease (EMPD) is a rare cutaneous intra-epidermal adenocarcinoma with a controversial origin, and frequently occurs in the penoscrotal region in males. Primary EMPD, which originates within the epidermis or apocrine glands, is usually an in situ disease confined to the epidermis with a good prognosis, while secondary EMPD is considered to be associated with underlying internal malignancy. EMPD in situ has the potential to become invasive EMPD which has a higher metastasis rate and worse prognosis. Thus, it is important to identify transcriptomic profiles related to the biological behavior of invasion to improve the treatment of invasive EMPD in the future.
Journal Title: Chinese Medical Journal
Year Published: 2022
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