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Regulation of mammalian target of rapamycin on ferroptosis: from mechanism to therapeutics in septic cardiomyopathy

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Sepsis refers to multiple organ dysfunction caused by the host ’ s dysfunctional response to infection. Most importantly, myocardial injury in septic patients, that is, septic cardiomyopathy (SIC), accounts for… Click to show full abstract

Sepsis refers to multiple organ dysfunction caused by the host ’ s dysfunctional response to infection. Most importantly, myocardial injury in septic patients, that is, septic cardiomyopathy (SIC), accounts for 1/3 to 1/2 of the total number of hospital deaths. The pathogenesis of SIC remains largely unclear, for which in-depth exploration is of great signi fi cance to improve the clinical prognosis of this patient population

Keywords: target rapamycin; septic cardiomyopathy; regulation mammalian; mammalian target; ferroptosis mechanism; rapamycin ferroptosis

Journal Title: Chinese Medical Journal
Year Published: 2022

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