LAUSR

To the Editor: Combined nuclei stimulation may have a synergistic effect on controlling the symptoms of nervous system diseases and improving quality of life. [1] However, increasing of leads may increase costs and complications. [2] Therefore, our study aims to investigate the safety and feasibility of the single curved lead, which can simultaneously reach both subthalamic nucleus (STN) and pedunculopontine nucleus (PPN). The animal experiment, which was ethically approved ([No. 2019] [234]) by the animal research ethical committee of the Second Af fi liated Hospital of Fujian Medical University, was performed complied with the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guideline. Twenty healthy adult male Sprague-Dawley rats weighing 290 – 310 g were randomly and equably assigned to four groups: (1) Sham-modeled group (Group A): all rats were injected with 3 m L of 0.9% saline containing ascorbic acid (0.2 mg/mL) into the right medial forebrain bundle (MFB); (2) Sham-operated group (Group B): all rats were injected with 3 m L 6-hydroxydopamine (6-OHDA) (3.5 m g/ m L) into the right MFB without lead implantation; (