LAUSR

To the Editor: Osteoarthritis (OA) is a prominent disabling disease characterized by progressive articular cartilage damage coupled with deterioration in the subchondral bone and other structures of the joint, and is ranked as the 12th highest disease contributing to global disability. [1] The course of knee OA is considerably long and can affect three knee compartments (the patellofemoral joint [PFJ], medial tibiofemoral joint [MTFJ], and lateral tibiofemoral joint [LTFJ]) alone or in combination, resulting in a large variation in the occurrence of cartilage damage in the three compartments. [2] We aimed to determine the baseline predictors associated with distinct tricompartmental trajectories of cartilage damage in knees at risk for OA.