Photo from wikipedia
To the Editor: Anaplastic lymphoma kinase (ALK) fusion oncogene occurs in 3% to 7% of patients with non-small cell lung cancer (NSCLC), with the most common companion being echinoderm microtubule-associated… Click to show full abstract
To the Editor: Anaplastic lymphoma kinase (ALK) fusion oncogene occurs in 3% to 7% of patients with non-small cell lung cancer (NSCLC), with the most common companion being echinoderm microtubule-associated protein-like 4. [1] Ceritinib is an oral, small-molecule, adenosine triphosphate (ATP)-competitive drug, and tyrosine kinase inhibitor of ALK (ALK-TKI) that is 20 times more potent than crizotinib in enzymological tests. [2] To date, there are few prospective clinical trials of neoadjuvant targeted therapy in patients with ALK-positive locally advanced NSCLC. Therefore, the value of ceritinib in ALK-positive stage IIIA (N2) NSCLC is unknown. In this study, we reported the ef fi ciency of ceritinib used as initial neoadjuvant targeted therapy in patients with ALK-positive IIIA (N2) NSCLC. A 48-year-old woman was
Journal Title: Chinese Medical Journal
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!