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Given the propensity for squamous neoplasms to develop within hypertrophic LP lesions and the histological similarities between reactive and neoplastic processes in this setting, distinguishing between the 2 can represent… Click to show full abstract
Given the propensity for squamous neoplasms to develop within hypertrophic LP lesions and the histological similarities between reactive and neoplastic processes in this setting, distinguishing between the 2 can represent a diagnostic challenge. Pseudoepitheliomatous hyperplasia needs to be accurately distinguished from squamous metaplasia. Lack of invasion into the dermis canbeauseful clue.Bowenandcolleagues suggested that p53 and Verhoeff–Van Gieson staining can be useful in distinguishing between keratoacanthoma and hypertrophic LP lesions, with keratoacanthomas showing increased p53 expression and perforating elastic fibers when compared with hypertrophic LP lesions. 5
Journal Title: Dermatologic Surgery
Year Published: 2017
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