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Tumor heterogeneity can influence the response of some cancers to treatment. At times, even targeted medications directed toward key signaling pathways may not be effective, posing a challenge in individual… Click to show full abstract
Tumor heterogeneity can influence the response of some cancers to treatment. At times, even targeted medications directed toward key signaling pathways may not be effective, posing a challenge in individual patient management. Herein, we report a case of locally advanced basal cell carcinoma (BCC), shown to have a PTCH mutation and absence of an SMO mutation, that was only partially responsive to vismodegib treatment, suggesting an alternative mechanism for resistance.
Keywords:
advanced basal;
tumor heterogeneity;
locally advanced;
cell carcinoma;
treatment;
basal cell
Journal Title: Dermatologic Surgery
Year Published: 2019
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Journal Title: Dermatologic Surgery
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!