LAUSR

Background: Although mercury exposure has been associated with several adverse health effects, the association with childhood asthma is under investigated. Therefore, we explore the association between mercury and childhood asthma in a population with low mercury levels. Methods: Mercury levels were measured in blood and urine in 1,056 children ages 5–14 years. In addition to including questions about asthma diagnosis and wheezing, the study measured bronchial hyperresponsiveness and allergic sensitization to common aeroallergens. Logistic regression analysis adjusted for major potential confounders. Results: Overall the adjusted odds ratios (aOR) between log blood mercury and the outcomes were 0.8 (95% CI: 0.63, 1.11) for asthma, 0.9 (95% CI: 0.79, 1.14) for wheeze, 1.1 (95% CI: 0.60, 2.03) for bronchial hyperresponsiveness, and 1.0 (95% CI: 0.80, 1.17) for allergic sensitization. Urine mercury adjusted for creatinine was also not associated with any of these allergy-related outcomes. Conclusions: While the results did not support an association between mercury exposure and asthma, studies are needed to assess prenatal and lifetime exposure to mercury and asthma.