LAUSR

Mitochondrial transplantation refers to the process of introducing isolated mitochondria into a damaged area of the heart or other organs. In the past decade, this technique has been continuously updated as the fundamental research on the repair of damaged cells or tissues. Particularly, in the field of heart protection from ischemia-reperfusion injury, the MT therapy has been developed to the clinical trial stage. Generally speaking, the goal of therapeutic intervention is to replace damaged mitochondria or increase the transfer of mitochondria between cells so as to improve mitochondrial dysfunction. In this review, we summarized the studies on mitochondrial transplantation conducted at different time nodes and outlined a range of different methods for delivering mitochondria into the target site. Finally, we described the applications of mitochondrial transplantation in different diseases, and discussed the clinical studies of human mitochondrial transplantation currently in progress as well as the problems that need to be overcome. We hope to provide new ideas for the treatment of mitochondrial defects related diseases.