LAUSR

Objective: In type 2 diabetes (T2D), increased arterial stiffening results from accelerated arterial wall matrix remodeling. The associated structural alterations modify the pressure dependency of arterial stiffness, which can be quantified by the systolic–diastolic difference in carotid pulse wave velocity (&dgr;PWV). We evaluated the association between T2D and &dgr;PWV as marker for matrix remodeling and whether &dgr;PWV may contain additional information beyond carotid stiffness (cPWV). Methods: In 746 individuals from The Maastricht Study, 415 with normal glucose metabolism; 126 with prediabetes; and 205 with T2D, carotid pulse wave velocity (cPWV) and &dgr;PWV were determined by ultrasonography and tonometry. Multiple linear regression analyses were used to investigate associations of glucose metabolism status (with normal glucose metabolism as reference) with cPWV and &dgr;PWV, adjusting for age, sex, mean arterial pressure, prior cardiovascular disease, estimated glomerular filtration rate and smoking, and &dgr;PWV or cPWV as appropriate. Results: After adjustment for age, sex, mean arterial pressure, prior cardiovascular disease, estimated glomerular filtration rate and smoking, T2D was associated with greater cPWV [&bgr; (95% confidence interval) 0.376 (0.119; 0.632)] and &dgr;PWV [0.301 (0.013; 0.589)]. After additional adjustment for &dgr;PWV or cPWV, associations of T2D with cPWV and &dgr;PWV were attenuated [0.294 (0.048; 0.539) and 0.173 (−0.103; 0.449), respectively]. Prediabetes was not associated with either cPWV or &dgr;PWV. Conclusion: The systolic-diastolic difference in carotid stiffness is increased in T2D, but not prediabetes. Importantly, the association was not abolished by carotid stiffness, which suggests that systolic–diastolic difference in carotid stiffness carries additional information regarding arterial matrix remodeling.