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Isolated systolic hypertension in young adults: a heterogeneous finding.

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H ypertension in adults has been extensively studied, with wide array of data about physiology, associated pathophysiology, different phenotypes, treatment, outcomes, and extensive sets of guidelines established in an attempt… Click to show full abstract

H ypertension in adults has been extensively studied, with wide array of data about physiology, associated pathophysiology, different phenotypes, treatment, outcomes, and extensive sets of guidelines established in an attempt to facilitate practice [1,2]. Hypertension in children was also studied though not as extensively, and in the absence of solid clinical outcomes for these age groups, research mostly employed variety of surrogate outcomes, such as left ventricular mass, intima/media thickness, and the like tohelp realizeclinicalmeaningof hypertension in childhood, as summarized in recent American Heart Association guidelines on hypertension in childhood [3]. Therefore, it may appear that we have detailed sets of guidelines both for children and for adults. Nevertheless, whereas childhood hypertension lasts about a decade, that of adults spans several decades, resulting in quite a heterogeneity in age, and subsequent characteristics and quite an age-dependent variability in outcomes. Indeed, at least when it comes to outcomes in studies of hypertension, they appear to segregate among higher risk (older among other aspects) adults; thus, most randomizedoutcome studies in latest years involvedhigh-risk individuals frequently older than 55 years. Thus we have guidelines based on randomized trials almost exclusively amongolder higher risk patients, whereas younger, standard, or low risk young adults are not well represented in the knowledge database we have about hypertension. Most if not all the information on hypertension in young adults stems from observational studies. Of particular interest are studies on military conscripts who are examined ahead of recruitment, and yield if not population-based estimates as say in the case of Israel, with its mandatory recruitment laws [4], to a sampleof conscriptswhichproduce an estimate and a rare samples of blood pressure (BP) in young adults in Sweden [5]. Such studies have the advantage of very large numbers, more than 2 million adolescents in an Israeli study

Keywords: risk; isolated systolic; hypertension young; hypertension; systolic hypertension; young adults

Journal Title: Journal of Hypertension
Year Published: 2018

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