LAUSR

INTRODUCTION In previous landmark studies on central retinal vein occlusion (CRVO), retinal non-perfusion assessments were obtained using 7-field (7F) angiography. The widespread current use of widefield (WF) imaging allows better visualization of the peripheral retina and more comprehensive estimation of the total area of non-perfusion. The relationship between non-perfusion measurement of 7F and WF angiography (WFA) in CRVO has not been studied. We aim to identify the correlation of retinal non-perfusion measured within the 7F and on WFA in eyes with central retinal vein occlusion. METHODS Retinal non-perfusion in participants with CRVO was determined using a 7F ETDRS template and the concentric rings method. RESULTS A total of 153 eyes were included. Pearson correlation test showed a near-perfect positive, linear correlation between the non-perfusion found in the 7F and total retinal non-perfusion on WFA (0.985 95% CI [0.793, 0.999]) The regression line equation for non-perfusion on 7F and WFA was y = 37 + 3.2x. Eyes with 0 disc areas (DA), >0DA - 10DA and >10DA of non-perfusion on 7-fields had on average 23DA 95%CI [19.20, 27.06], 45DA 95% CI [35.75, 55.18], and 115DA 95%CI [88.89, 142.05] on WF respectively. CONCLUSIONS There is a positive and linear relationship between non-perfusion measured by 7F and WFA in CRVO with more than 3-times the amount of non-perfusion identified on WFA. Despite <10DA no areas of non-perfusion on 7F, there is typically at least 35DA of non-perfusion on WFA while eyes with >10DA of non-perfusion on 7F had at least 88DA on WFA.