LAUSR

Supplemental Digital Content is Available in the Text. In this retrospective study of 94 eyes with idiopathic intermediate, posterior, and panuveitis, macrostructural and microstructural structural abnormalities on optical coherence tomography were notable in a large proportion of eyes at baseline and throughout follow-up. Purpose: To characterize optical coherence tomography features in patients with idiopathic intermediate, posterior, or panuveitis. Methods: This is a retrospective case series of all consecutive cases of idiopathic intermediate, posterior, or panuveitis at four tertiary care centres between 2010 and 2021. Results: A total of 94 eyes (55 patients) were followed for an average duration of 29.8 (SD 21) months. The median central macular thickness was 284 µm at baseline and 267 µm at last follow-up. At baseline and last follow-up, respectively, 24% and 20% of uveitic eyes had intraretinal fluid, 12% and 1% subretinal fluid, and 43% and 54% epiretinal membrane. In addition, ellipsoid zone abnormalities on en-face were noted in 34% and 19% of cases at baseline and last follow-up, respectively. The baseline median visual acuity was significantly lower among cases with ellipsoid zone en-face slab abnormalities compared with those without (0.2 logarithm of minimum angle of resolution [interquartile range: 0–0.6] vs. 0.1 logarithm of minimum angle of resolution [interquartile range: 0–0.3], P = 0.0051). Conclusion: With initiation of treatment, the central macular thickness, intraretinal fluid, subretinal fluid, and ellipsoid zone en-face abnormalities improved over time, whereas the number of cases with epiretinal membrane increased among eyes with idiopathic intermediate, posterior, and panuveitis. Presence of ellipsoid zone en-face abnormalities at presentation may be associated with worse visual acuity.