LAUSR

Supplemental Digital Content is Available in the Text. A novel Heterogeneous Data Fusion Net enabled visual outcome prediction for idiopathic epiretinal membrane surgery to assist with surgical decision making through multimodal fusion of numerical clinical data and preoperative optical coherence tomography images. Purpose: To develop a deep convolutional neural network that enables the prediction of postoperative visual outcomes after epiretinal membrane surgery based on preoperative optical coherence tomography images and clinical parameters to refine surgical decision making. Methods: A total of 529 patients with idiopathic epiretinal membrane who underwent standard vitrectomy with epiretinal membrane peeling surgery by two surgeons between January 1, 2014, and June 1, 2020, were enrolled. The newly developed Heterogeneous Data Fusion Net was introduced to predict postoperative visual acuity outcomes (improvement ≥2 lines in Snellen chart) 12 months after surgery based on preoperative cross-sectional optical coherence tomography images and clinical factors, including age, sex, and preoperative visual acuity. The predictive accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve of the convolutional neural network model were evaluated. Results: The developed model demonstrated an overall accuracy for visual outcome prediction of 88.68% (95% CI, 79.0%–95.7%) with an area under the receiver operating characteristic curve of 97.8% (95% CI, 86.8%–98.0%), sensitivity of 87.0% (95% CI, 67.9%–95.5%), specificity of 92.9% (95% CI, 77.4%–98.0%), precision of 0.909, recall of 0.870, and F1 score of 0.889. The heatmaps identified the critical area for prediction as the ellipsoid zone of photoreceptors and the superficial retina, which was subjected to tangential traction of the proliferative membrane. Conclusion: The novel Heterogeneous Data Fusion Net demonstrated high accuracy in the automated prediction of visual outcomes after weighing and leveraging multiple clinical parameters, including optical coherence tomography images. This approach may be helpful in establishing personalized therapeutic strategies for epiretinal membrane management.