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RETINOBLASTOMA ASSOCIATED WITH TOTAL EXUDATIVE RETINAL DETACHMENT

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Analysis of 50 eyes with retinoblastoma-associated total retinal detachment revealed tumor regression with retinal attachment in 82% eyes, tumor recurrence in 78% eyes, and globe salvage in 70% eyes over… Click to show full abstract

Analysis of 50 eyes with retinoblastoma-associated total retinal detachment revealed tumor regression with retinal attachment in 82% eyes, tumor recurrence in 78% eyes, and globe salvage in 70% eyes over a mean follow-up period of 30 months (median, 29 months; range, 7–62 months). Purpose: To study the clinical presentation, treatment, and outcomes of eyes presenting with retinoblastoma and total retinal detachment. Methods: A retrospective study of 50 eyes in 43 patients. Results: The mean age at presentation was 15 months (median, 9 months). Retinoblastoma-associated total retinal detachment was unilateral (n = 36; 84%) or bilateral (n = 7; 16%). The mean tumor basal diameter was 17 mm (median, 18 mm), and the mean tumor thickness was 13 mm (median, 12 mm). Associated features included subretinal seeds (n = 26; 52%), vitreous seeds (n = 13; 26%), and subretinal exudation (n = 4; 8%). Based on eighth edition of American Joint Committee on Cancer classification, the tumors were classified as cT2a (n = 19; 38%), cT2b (n = 28; 56%), or cT3c (n = 3; 6%). Primary treatment included intravenous (n = 48; 96%) or intraarterial chemotherapy (n = 2; 4%). Over a mean follow-up period of 30 months (median, 29 months; range, 7–62 months), retinal detachment resolved in 41 eyes (82%), tumor recurrence was noted in 39 eyes (78%), globe salvage was achieved in 35 eyes (70%), and one patient (2%) died due to metastasis. Conclusion: Relatively high tumor recurrence rate is noted in retinoblastoma presenting with total retinal detachment. With appropriate treatment, 70% of the globes can be salvaged.

Keywords: retinal detachment; retinoblastoma associated; associated total; tumor; detachment

Journal Title: Retina
Year Published: 2023

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