LAUSR

PURPOSE To describe and quantify the abnormalities of the retinal capillary plexuses using OCT angiography in Coats' disease. METHODS Retrospective study. Eleven eyes of 11 patients with Coats' disease (9 men and 2 women aged 32 to 80 years) compared to 9 fellow eyes and 11 healthy control eyes.Horizontal bands of contiguous 3 x 3 mm OCT angiograms of the superficial vascular plexus (SVP) and deep capillary complex (DCC) were acquired from the optic disc to 6 mm temporal to the fovea, through areas with telangiectasia visible on fluorescein angiography in 9 cases. MAIN OUTCOME MEASURES Vascular density (VD) and fractal dimension (FD). RESULTS The VD was significantly decreased in both plexuses in eyes with Coats' disease compared to normal and fellow eyes within the 6 mm temporal to the fovea (SVP: 21.5 versus 29.4 %, p=0.00004 and versus 30.3%, p= 0.00008. DCC, 16.5 versus 23.9%, p=0.00004 and versus 24.7%, p=0.00008, respectively). The FD was also significantly decreased in eyes with Coats' disease (SVP: 1.796 versus 1.848 p=0.001 and versus 1.833, p=0.003. DCC: 1.762 versus 1.853, p=0.003 and versus 1.838, p=0.004, respectively). CONCLUSION Retinal plexuses' VD was decreased in Coats' disease, including in areas with no visible telangiectasia.