LAUSR

PURPOSE To describe the successful outcome of simultaneous allogenic simple limbal epithelial transplantation (SLET) combined with therapeutic penetrating keratoplasty (PKP) for limbal stem cell deficiency (LSCD) with sterile keratolysis after bilateral chemical injury. METHODS A 37-year-old man presented with total LSCD and sterile keratolysis with perforation in the left eye after amniotic membrane transplantation for bilateral chemical injury before 3 months. The right eye had a stable ocular surface, absence of palisades of Vogt, and minimal anterior stromal scarring. To salvage the left eye, emergency therapeutic PKP combined with allogeneic SLET was performed. He was given oral steroids for 8 weeks and mycophenolate mofetil for 1 year to prevent allograft rejection. RESULTS At the last follow-up, 2 years later, with miniscleral contact lens, his best corrected visual acuity was 20/20 with a clear graft and an intact ocular surface. CONCLUSIONS To the best of our knowledge, this is the first report of successful outcome of emergency PKP with simultaneous allogeneic SLET managed by systemic immunosuppression for corneal perforation with LSCD.