LAUSR

PURPOSE To compare the effect of mannitol in reducing intraocular pressure (IOP) in vitrectomized and non-vitrectomized eyes. METHODS Prospective comparative case study. Eyes with IOP ≥40▒mm Hg were included. Eyes which are vitrectomized and silicon oil filled were classified as group 1, and non-vitrectomized open angle eyes were classified as group 2. Mannitol (20%, 1▒g/kg) was administered intravenously over 30 minutes, and IOP was recorded at 30 minutes interval till 2 hours and at the 3 and 4 hour from the start of mannitol. RESULTS Thirty eyes (patients) were recruited in each group. Mean (SD) IOP reduced from 48.5±5.2 to 43.7±8 at 30 minutes, 40.7±8.4 at 60 minutes, 37.3±9.6 at 90 minutes, 35.6±10.4 at 2 hours, 34±10.7 at 3 hours and 33±11.2▒mm Hg at 4 hours in group 1, and from 48.9±6.5 to 43.2±8.6 at 30 minutes, 40.2±7.8 at 60 minutes, 36.7±7.3 at 90 minutes, 35.1±7.7 at 2 hours, 34.2±8.8 at 3 hours and 35.7±9.4▒mm Hg at 4 hours in group 2. There was significant reduction in IOP at each time point compared to baseline in both the groups (P < 0.001). There was no significant difference in IOP between the 2 groups at each time point. CONCLUSIONS Mannitol reduces IOP significantly in both vitrectomized and non-vitrectomized eyes.