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PRCIS Optical microangiography measurements correlated with functional parameters in glaucoma patients. OCTA-derived VPD better reflected the structure-function relationship than flux index and RNFL thickness. PURPOSE To compare the structure-function relationship between peripapillary optical microangiography (OMAG) measurements and standard automated perimetry (SAP) loss by comparison with peripapillary retinal nerve fiver layer (pRNFL) thickness in primary open-angle glaucoma. METHODS One eye from each of 128 patients with early-to-severe glaucoma (including preperimetric glaucoma) and 23 normal participants underwent optic nerve head scanning of the radial peripapillary capillaries and pRNFL scans with OMAG centered on the optic disc and SAP (mean age: 67.8±12.0▒y; SAP mean deviation: -5.84±6.6▒dB). Regional relationships between vessel perfusion density (VPD), flux index (FI), pRNFL thickness, and corresponding SAP sensitivity were compared using linear and fractional polynomial (FP) models. RESULTS Structure was significantly related to function for all but the nasal pRNFL thickness region. For VPD, the coefficient of determination (R2) using the FP model was significantly stronger than that of the linear model (FP: 0.25-0.67, linear: 0.19-0.61), while no difference was found for FI in any region (FP: 0.19-0.44, Linear: 0.15-0.42). R2 for VPD was stronger than FI and pRNFL (FP: 0.11-0.52, Linear: 0.01-0.44) in inferior and superior regions, while VPD and FI were not different in temporal and nasal regions. CONCLUSIONS VPD showed a stronger association with visual field loss than flux index or RNFL thickness except in the temporal region. The FI relationship was weak, but more linear around the peripapillary region. The strength of the structure-function relationship may be different depending on the region and OMAG measurements.