LAUSR

PURPOSE To compare the pattern of vascular density and structural damage in primary open angle glaucoma (POAG) with primary angle-closure glaucoma (PACG) using OCT and OCT angiography (OCTA) in the optic nerve head, circumpapillary, and macular regions. METHODS One hundred and thirty-one eyes of 82 patients (53 eyes with PACG and 78 eyes with POAG) were enrolled into this study. Patients underwent complete ophthalmic examination, Bruch's membrane opening minimum rim width (BMO-MRW), circumpapillay retinal nerve fiber layer (cpRNFL), and macular ganglion cell complex (GCC) measurements and vascular density determination of the peripapillary and macular area with OCT and OCTA. Linear mixed model was used for statistical analysis. RESULTS There was no significant difference between the two groups in terms of age(P=0.94) and visual field mean deviation (P=0.78). Female-to-male ratio was higher in PACG patients than POAG group(P=0.02), and AL was shorter in PACG eyes(P<0.001). cpRNFL and GCC were not different between the 2 groups (all P values >0.05, except for nasal segment cpRNFL). Vessel densities in the peripapillary and macular areas were comparable between the 2 groups (all P values>0.05). Although BMO-MRW was thicker in PACG eyes on univariate analysis, multivariable analysis showed no significant difference between the 2 groups(P>0.05). CONCLUSIONS PACG and POAG eyes with similar visual field damages have comparable structural damage patterns in the peripapillary and inner macular thickness and vessel density measurements.