LAUSR

PRCIS The dynamic parameters of the pupil, evaluated with an automated pupillometry device, differ in newly diagnosed early-stage primary open angle glaucoma patients compared to healthy individuals, and this may guide us in early diagnosis and follow-up of glaucoma. INTRODUCTION AND AIM To quantitatively determine static and dynamic pupillary functions in treatment-naive, newly diagnosed early-stage primary open angle glaucoma (POAG) patients and compare them with healthy controls. METHODS Forty eye of forty subjects with early POAG were compared with 71 eye of 71 age- and sex-matched healthy controls in terms of static and dynamic pupillary functions in this prospective and cross-sectional study. Static and dynamic pupillary functions were obtained with an automated pupillometry device. Static pupillometry parameters are pupil diameter (PD, mm) in high-photopic (100 cd/m2), low-photopic (10 cd/m2), mesopic (1 cd/m2), and scotopic (0.1 cd/m2) light conditions. Dynamic pupillometry parameters are resting diameter (mm), amplitude (mm), latency (ms), duration (ms) and velocity (mm/s) of pupil contraction and dilation. Measured data were evaluated and compared with t-test for independent groups. RESULTS Duration of pupil contraction was lower, (P=0.04) latency of pupil dilation time was longer, (P=0.03) duration of pupil dilation was shorter (P=0.04) and velocity of pupil dilation was lower (P=0.02) in the POAG group. There was no significant difference between the two groups in terms of static pupillometry characteristics and the resting PD (P>0.05 for all values). CONCLUSION These results suggest that dynamic pupillary light responses may be affected in early-stage POAG compared to the normal population. Longitudinal studies with larger series are needed to better understand the quantitative changes in dynamic pupillometry functions in early-stage POAG.