LAUSR

PURPOSE To analyze new-onset mental and behavioral disorders and nervous system diseases in cataract patients implanted either with non-BLF or BLF IOLs in both eyes. SETTING Department of Ophthalmology, Kymenlaakso Central Hospital, Kotka, Finland. DESIGN A retrospective registry-based cohort study of patients operated between September 2007 and December 2018 who were followed until December 2021. We included 4986 patients who underwent bilateral cataract surgery. METHODS Patients were implanted with either non-BLF IOLs (N=2609) or BLF IOLs (N=2377) in both eyes. Follow-up before the first eye and between the first and second eye surgery was performed to acknowledge the pre-existing disorders and diseases. After the second eye surgery the groups were analyzed for the new-onset mental and behavioral disorders and diseases of the nervous system subcategorized by the International Classification of Diseases (ICD) codes. RESULTS 1707 male and 3279 female patients, aged 73.2±8.6 years at the first eye and 74.3±8.8 years at the second eye surgery were identified. In univariate log-rank tests the use of BLF IOLs showed no association in overall new-onset disorders or diseases over non-BLF IOLs, in any subtype diagnosis codes except for sleep disorders, which favored BLF IOLs (p=0.003). A multivariable analysis adjusted for age and gender identified no associations in any new-onset disorders or diseases. Multivariable analysis of sleep disorders showed a non-significant advantage for BLF-IOLs (HR 0.756, 95% CI 0.534-1.070, P=0.114). CONCLUSIONS BLF IOLs were not associated with mental and behavioral disorders or diseases of the nervous system.