LAUSR

W e appreciate the comments of Chirico and Szarpak and their efforts to elucidate several important issues related to antigen testing in the employment setting. We agree that screening testing is one part of a comprehensive approach to reducing transmission in workplaces, which also includes vaccination, risk assessments, contact tracing, physical distancing, and mask use. Chirico and Szarpak reiterated the false negative issue in persons with low viral load but confirmed the utility of antigen testing in those with high viral load and no symptoms. They noted that the cost of antigen testing may be an issue in some countries, and this is true. However, in many countries the costs should be within the range of doing business and not constraining. In addition, it is important to consider the potential cost savings and other benefits associated with preventing workplace transmission of SARS-CoV-2. We agree with the point raised that there is more to the costs than the cost of the actual test and emphasize that there is also the need for contact tracing and trained personnel. As we had discussed in our manuscript, Chirico and Szarpak also noted there are ethical and legal issues surrounding testing programs that require attention and resources. They highlight the role of occupational physicians in many activities surrounding COVID-19 precautions and control that we discussed, including education of workers, testing, contract tracing,