LAUSR

The present manuscript describes vaccine responses among individuals from a North American gaming/entertainment venue, a workforce severely impacted COVID-19. Data demonstrate reduction in infections concomitant with vaccination and identify potentially important differences in response depending upon vaccine type, prior COVID-19, autoimmunity, and age, but not occupational risk factors. Objective This study aims to evaluate COVID-19 cases and vaccine responses among workers in the gaming/entertainment industry. Methods Participants provided detailed information on occupational risk factors, demographics, COVID-19 history, and vaccination status through questionnaire. Enzyme-linked immunosorbent assays were used to measure serum antiviral antibodies and neutralizing capacity. Results Five hundred-fifty individuals participated with n = 228 (41.5%) returning for follow-up. At least 71% of participants were fully vaccinated within 8 months of vaccine availability and COVID-19 rates declined concomitantly. Serum anti–spike IgG levels and neutralizing capacity were significantly (P < 0.001) associated COVID-19 history and vaccine type, but not occupational risk factors, and declined (on average 36%) within 5 months. Few vaccine nonresponders (n = 12) and “breakthrough” infections (n = 1) were noted. Conclusions COVID-19 vaccination was associated with a marked decrease in infections; however, individual humoral responses varied and declined significantly over time.