LAUSR

OBJECTIVE To examine changes in work productivity and daily activity impairment among women by starting ethinylestradiol (EE)/drospirenone (DRSP) for perimenstrual symptoms. METHODS Participants were women who were newly prescribed EE/DRSP at 25 gynecological clinics in Japan. Eligible participants recorded daily intake of EE/DRSP and the Work Productivity Activity Impairment Questionnaire General Health (WPAI-GH) every two weeks for three months by smartphone app. A linear mixed-effects model was used to see changes in work work productivity impairment and activity impairment relative to baseline. RESULTS Work productivity impairment recovered by 20.0% (95%CI: 14.1-26.0%) at 1 m and maintained for two months. Activity impairment recovered by 20.1% (95% CI:15.5-24.7%) at 1 m and thereafter. CONCLUSIONS Improvements in work productivity and daily activities were observed at 1 m after EE/DRSP initiation, with a sustained effect thereafter.