LAUSR

available at http://www.ncbi.nlm.nih.gov/pubmed/30588784 Editorial Comment: Patients with nonseminomatous testicular cancer can be subfertile or infertile for unknown reasons. These authors compared the sperm proteome of 15 such patients who cryopreserved their sperm before treatment with that of 15 healthy fertile men. Semen volume, and sperm motility and concentration were evaluated before cryopreservation of samples from both groups. Sperm proteomic analysis was used to evaluate differentially expressed proteins between the 2 groups. Among 189 differentially expressed proteins the authors noted under expression of mitochondrial complex subunits NADH:ubiquinone oxidoreductase core subunit S1 and ubiquinol-cytochrome C reductase core protein 2 in patients with nonseminomatous testicular cancer. These results indicate that sperm mitochondrial dysfunction may explain the decrease in sperm concentration, total sperm count and sperm motility in patients with nonseminomatous germ cell tumors. Jerome P. Richie, MD