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available at http://www.ncbi.nlm.nih.gov/pubmed/31036339 Editorial Comment: Parental obesity increases the risk of obesity in offspring, likely through an epigenetic pathway that may take generations of work to undo. This deep review of the impact of parental overweight and underweight on the health of offspring contains a treasure trove of information on what adverse health conditions such as the metabolic syndrome, cancer, neurological disorders and others derive from parental obesity. What is shocking to realize is that parental underweight may also be associated with metabolic and neurological disorders. We are in the middle of an obesity epidemic, and the most obvious solution of caloric restriction comes with its own risks. Craig Niederberger, MD Suggested Reading Raman JD and Schlegel PN: Aromatase inhibitors for male infertility. J Urol 2002; 167: 624. Re: Parental Age and Child Outcomes C. Bergh, A. Pinborg and U. B. Wennerholm Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University and Reproductive Medicine, Sahlgrenska University Hospital and Sahlgrenska University Hospital East, Gothenburg, Sweden, and Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Fertil Steril 2019; 111: 1036e1046. doi: 10.1016/j.fertnstert.2019.04.026 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/31155113 Editorial Comment: The relationship between increasing maternal age and child outcomes such as trisomy 21 is well known. However, other effects of maternal age and those of paternal age are less well understood by medical practitioners at large. This excellent systematic review details those relationships in chromosomal aberrations, birth defects, cancer, type 1 diabetes, asthma, cerebral palsy, neurodevelopment, and psychiatric and cognitive disorders. For each adverse outcome the authors list the evidence for maternal age followed by paternal age, making for an extraordinary reference for any physician treating infertility. Patients ask about age effects all the time, and here is an exhaustive modern resource. Craig Niederberger, MD Suggested Reading van der Zanden LF, Galesloot TE, Feitz WF et al: Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias. J Urol 2012; 188: 2354. 450 MALE INFERTILITY Copyright © 2020 American Urological Association Education and Research, Inc. Unauthorized reproduction of this article is prohibited.