LAUSR

PSA, surgery year, surgical center, clinical stage, margins status, extracapsular extension, seminal vesicle invasion, lymph node status, and pathological grade group. The associations between diabetes and PCSM, CRPC and metastases were determined in the entire cohort and stratified by obesity (BMI: non-obese <30 kg/m; obese 30 kg/m). Interactions between obesity and diabetes were evaluated in fully adjusted models. RESULTS: Of 4688 men identified, 20% (n[955) were diabetic and 33% (n[1560) were obese at RP. During a median follow-up of 8 years, 102 men had PCSM, 133 had CRPC and 201 had metastases. In adjusted models, in obese men, diabetes was associated with increased PCSM (HR[3.56; 95%CI: 1.69-7.54), CRPC (HR[2.46; 95%CI: 1.28-4.72), and metastases (HR[1.69; 95%CI: 0.99-2.90), although the HR for metastases was not statistically significant. In non-obese men, all associations between diabetes and outcomes were null. The interaction terms for diabetes and obesity were statistically significant for PCSM (p[0.002), CRPC (p[0.004) and metastases (p[0.012). CONCLUSIONS: Our findings suggest that following RP, diabetes is a risk factor for PC progression and mortality in obese men, but not non-obese men. If confirmed in future studies, understanding the mechanistic underpinnings for these associations may shed important light on PC tumor biology.