LAUSR

features, which was applied to all patients. The Cox model output a risk score for each patient. This process was termed “Histotyping”. The concordance index (c-index) of Histotyping and Decipher in BCRfree survival were compared. RESULTS: The nine features selected by the Cox model included seven measures of average lumen shape and variation of lumen shape, one feature of lumen arrangement, and one feature of image texture. A greater variation across the tumor in lumen shape and density and a less smooth image texture were associated with increased BCR risk. Histotyping performed comparably to Decipher (cindex 0.66 vs. 0.70) in BCR prognosis. CONCLUSIONS: Computerized visual analysis of a routinely acquired H&E slides was found to perform comparably to Decipher in BCR prognosis. A limitation of this work is that Decipher is optimized for metastasis prognosis, though metastasis outcome information was not available for these patients.