LAUSR

composite outcome was 9 months (range 0e84). When comparing same stage groups, those classified using MRI showed improved PFS on Kaplan-Meier curves compared to the same stage classified by DRE. The difference was significant in the T1 and T3 groups. Univariable analysis showed that patients with DRE T1 disease (HR 0.10 95%, CI 0.01-0.73, p[0.02) or DRE T3 (HR 0.70, CI 0.51-0.97, p[0.03) were at higher risk for failure. Multivariable analysis was performed in a subgroup fashion, comparing corresponding DRE and MRI stages corrected for age, grade group and PSA. Only DRE T1 remained a significant predictor for worst outcome (HR 0.08, CI 0.010.59, p[0.01). CONCLUSIONS: Our results suggest that stage classified by MRI rather than DRE leads to a possible Will Rogers phenomenon. Current risk groups were developed and validated on clinical stage and should be used with caution when counselling patients in whom local stage is often based on MRI.