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available at http://pubmed.ncbi.nlm.nih.gov/32192361 Editorial Comment: A large body of evidence documents that erectile dysfunction (ED) represents not only a complication of cardiovascular (CV) disease, but often an early sign of impending CV disease. These authors collected all of the available data from meta-analyses evaluating the association between ED and CV risk, as well as all available meta-analyses investigating the significance of ED as a possible early marker of major adverse cardiovascular events. The authors conclude available evidence indicates that ED represents a risk factor for CV related mortality and morbidity. In addition to conventional CV risk factors, unconventional factors derived from a perturbation of the relational and intrapsychic domains of ED may have a role in CV risk stratification of subjects with ED. Importantly penile Doppler ultrasound can provide information on CV risk, especially in younger and low risk subjects. Thus, the presence of ED should become an opportunitydfor the patient and the physiciandto screen for the presence of comorbidities, improving not only sexual health but, more importantly, men’s overall health. Very important data to bear in mind. Allen D. Seftel, MD Suggested Reading Zhou CK, Advani S, Chaloux M et al: Trends and patterns of testosterone therapy among U.S. male Medicare beneficiaries, 1999 to 2014. J Urol 2020; 203: 1184. MALE AND FEMALE SEXUAL FUNCTION AND DYSFUNCTION; ANDROLOGY 601 Copyright © 2020 American Urological Association Education and Research, Inc. Unauthorized reproduction of this article is prohibited.