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Recalcitrant vulvar pyoderma gangrenosum successfully treated with mycophenolate mofetil

Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis characterized by recurrent, painful, ulcerations. 1 Treatment typically involves anti-inflammatory agents, includ- ing corticosteroids, calcineurin inhibitors, antimetabolites, and TNF-alpha inhibitors. 1 We… Click to show full abstract

Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis characterized by recurrent, painful, ulcerations. 1 Treatment typically involves anti-inflammatory agents, includ- ing corticosteroids, calcineurin inhibitors, antimetabolites, and TNF-alpha inhibitors. 1 We present a case of vulvar PG, mimick-ing vulvar cellulitis and refractory to steroids, with successful response to mycophenolate mofetil (MM). A 47-year-old female was referred to our clinic with a 2-month history of multiple, recurrent, and painful ulcerations on the vulva, perineum, and buttocks and a 1-year history of oral ulcerations, and daily joint pain. She had previously been treated for vulvar cellulitis without improvement and had sub- sequent development of ulcerations. She denied family history of inflammatory bowel disease, Behcet’s, or other connective tissue disorders.

Keywords: vulvar; pyoderma gangrenosum; mycophenolate mofetil

Journal Title: International Journal of Women's Dermatology
Year Published: 2022

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