LAUSR

Supplemental Digital Content is available in the text. Introduction Improvements in coronary drug-eluting stent technology has focused on reducing the long-term complications associated with the effects of the residual footprint on the vessel wall. Although many of the newer stents have exhibited noninferiority to the durable polymer everolimus-eluting stent (DP-EES), they have yet to exhibit clear superiority. We compared the performance of the latest ultrathin strut biodegradable polymer sirolimus-eluting stents (BP-SES) to DP-EES. Methods We searched the electronic databases for randomized controlled trials comparing BP-SES to DP-EES. A random effect meta-analysis was performed using the Poisson regression model. The primary end point was target lesion failure (TLF), a composite of target vessel myocardial infarction (TVMI), cardiac death and target lesion revascularization (TLR). Results There was no difference between the stents in stent thrombosis [incidence rate ratio (IRR) = 0.79, 95% confidence interval (CI) 0.58–1.06), TLR (IRR = 0.88, 95% CI 0.57–1.38), TVMI (IRR = 0.79, 95% CI 0.61–1.01), cardiac death (IRR = 0.99, 95% CI 0.76–1.29) and target vessel failure (IRR = 0.82, 95% CI 0.64–1.06). In addition, there was no difference in TLF (IRR = 0.82, 95% CI 0.64–1.06). There was evidence of reduced TLF in small vessels with BP-SES based on definition used (defined as ≤2.75 mm; IRR 0.64, 95% CI 0.46–0.91 versus ≤3 mm; IRR 1.11, 95% CI 0.90–1.36). Conclusion In our study, the performance of the latest generation BP-SES was comparable to DP-EES but failed to show superiority. The possible benefit in patients with small vessels should be explored future trials.