LAUSR

Introduction Russell-Silver syndrome (RSS, OMIM 180860) is a prenatal-onset growth insufficiency syndrome characterized by intrauterine growth restriction, postnatal growth failure, relative macrocephaly, frontal bossing, asymmetry, and feeding difficulty (Silver et al., 1953; Russell, 1954; Wakeling et al., 2017). Associated features include triangular faces, blue sclera, café-aulait spots, and genital malformations. Hand and digit anomalies have also been described, classically fifth finger brachyclinodactyly, although more involved malformations have been reported (reviewed in Moss and Switzer, 1983).