LAUSR

Abstract Background: This study aims to explore the effect of melatonin for the management of endometriosis. Methods: We will search electronic databases (Cochrane Library, MEDLINE, EMBASE, CINAHL, Web of Science, Scopus, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure) from their inceptions to the February 29, 2020 without language and publication time limitations. The study identification, study quality assessment, and data extraction will be undertaken by two separate researchers. We will also appraise evidence quality of main outcomes by Grading of Recommendations Assessment Development and Evaluation, and statistical analysis performance by RevMan 5.3 Software. Results: This study will summarize up-to-date clinical evidence to investigate the effect of melatonin for the management of endometriosis. Conclusion: This study may provide helpful evidence of melatonin for the management of endometriosis. Systematic review registration: INPLASY202040093.