LAUSR

RATIONALE Myxoid liposarcoma (MLS) is an extremely rare tumor of the salivary gland and it arises from undifferentiated pluripotent mesenchymal cells. We report a rare case of a primary MLS in the parotid gland. PATIENT CONCERNS The patient was a 49-year-old female who presented with a hard fixed mass in the left parotid region. DIAGNOSIS On computed tomography and MR images, this tumor has a low attenuation center with a thick enhancing wall and ill-defined margins. The absence of high-signal-intensity foci on T1-weighted images makes a MLS indistinguishable from most other soft-tissue masses. Pathologically, the tumor was diagnosed as MLS. INTERVENTIONS The patient received total parotidectomy with facial nerve preservation and selective neck dissection. OUTCOMES Immediate facial nerve function was House Brackmann Grade III and recovered within 3 months after the surgery. Follow-up period is 57 months and there was no recurrence until now. LESSONS In this report, we report a rare case of primary MLS mimicking a cystic lesion of the parotid gland.