LAUSR

RATIONALE Adenosquamous carcinoma of the scrotum is a rare cancer associated with poor prognosis. It is diagnosed through the presence of both adenocarcinoma and squamous cell carcinoma. PATIENT CONCERNS It may be difficult to diagnose at early stages and may have poor survival. DIAGNOSES We report a case of adenosquamous carcinoma of the scrotum in a 58-year-old male patient who presented with left scrotal mass for >1 year. INTERVENTIONS This is the first case in the literature of primary adenosquamous carcinoma of the scrotum managed successfully with surgery and post-surgery chemotherapy and radiotherapy. OUTCOMES The patient remained disease-free for 10 months postoperatively. LESSONS The surgery treatment combined with postoperative radiotherapy and chemotherapy can improve the survival of adenosquamous carcinoma.